Maria Rosa Ciriolo     bandiera-inglese

ciriolo122x155POSIZIONE ATTUALE
Professore Ordinario, Dipartimento di Biologia, Università di Roma “Tor Vergata”.
Capo della sezione di “Biochimica dell’Invecchiamento” Centro Ricerche, IRCCS San Raffaele “La Pisana” Roma.
FORMAZIONE
1980 Università di Roma “La Sapienza” : Dottore in Biologia cum laude
1988 University of Yeshiva, New York, NY, USA: Specializzazione in Farmacologia with honors
CRONOLOGIA DI IMPIEGO
1980-1983: Borsista, Ist. di Biochimica, Università di Roma “La Sapienza”, Roma
1983-1994: Ricercatore, Università di Roma “Tor Vergata”, Roma
1986-1988: Research associate, Yeshiva University, New York, NY (USA)
1994-2002: Professore Ordinario, Università di Chieti “G. D’Annunzio”, Chieti
2002- ad oggi: Professore Ordinario, Università di Roma “Tor Vergata”, Roma
2007- ad oggi: Capo del Laboratorio “Biochimica dell’invecchiamento” IRCCS San Raffaele, Roma
INSEGNAMENTI
Biochimica – Corso di Laurea Triennale in Scienze Biologiche
Proteine e Metabolismo – Corso di Laurea Magistrale in Biologia Cellulare e Molecolare
Biochimica – Corso di Laurea a ciclo unico in Pharmacy
Biochimica della Nutrizione – Corso di Laurea Magistrale in Scienze della Nutrizione
Laboratorio di Biochimica – Corso di Laurea Triennale in Scienze Biologiche
MEMBRO DI SOCIETA’
Società Italiana di Biochimica (SIB); Ordine Nazionale dei Biologi; Society for Free Radical Research (SFRR); Consorzio I.N.B.B. (Istituto Nazionale Biostrutture e Biosistemi); National Health committee on the evaluation of copper risk assessment; European Cell Death Organization (ECDO); INCT Redoxoma.
EDITORIAL BOARD MEMBER
Genes & Nutrition; The open Nitric Oxide Journal; Frontiers in Cancer Molecular Targets and Therapeutics; MAP Kinase; Trends in Cell & Molecular Biology.
Attività di revisore per Riviste Scientifiche Internazionali, quali: Antioxidants & Redox Signaling, Archives of Biochemistry and Biophysics, Autophagy, Biochemical Journal, Biochimica et Biophysica Acta, Cell death & Diseases, Cell Death and Differentiation, Cellular and Molecular Life Sciences, Current Medicinal Chemistry, European Journal of Pharmacology, Experimental Biology and Medicine, Free Radical Biology and Medicine, Journal of Inorganic Biochemistry, Journal of Neurochemistry, Life Sciences, Molecular Carcinogenesis, Molecular nutrition and Food Research, Mutation Research, Nature Chemical Biology, Neurological Sciences, Neuroscience, Pharmacology Research, PLOS ONE.
ATTIVITA’
- Member of the National board reviewer of the Italian Ministry of Education, Universities and Research;
- Referee per VQR (Evaluation of Research Quality);
- Grant reviewer for “Regione Calabria”, University of Padua; Israel Science Foundation; National Science Center of Poland.
- Guest Editor for Antioxidants & Redox Signaling and International Journal of Cell Biology.
- Task Force Member (Validation Team) of the Halifax Project “Getting to Know Cancer”.
PRODUTTIVITÀ E IMPATTO SCIENTIFICO
Autore di oltre 150 lavori pubblicati su riviste scientifiche “peer-reviewed”; 16 capitoli di libri e 110 abstracts a Congressi Nazionali ed Internazionali. (H-index 38, Total citations >3600)

FONDI (ultimi 5 anni)
- CEPID – Centros de Pesquisa, Inovação e Difusão No. 2013/07937-8 Redoxome – Redox Process in Biomedicine (2013-2018).
- MIUR– PRIN 2009, M8FKBB (Coordinatore Scientifico Nazionale), “Redox regulation of pathways involved in cellular senescence and in the age-related diseases” (2011-2013).
- FAPESP – No. 11/50318-1 Desenvolvimento de Compostos com Interesse Farmacológico ou Medicinal e de Sistemas para seu Transporte, Detecção e Reconhecimento no Meio Biológico (2011-2016).
- AIRC– IG – Study of the molecular players that regulate redox state, glucose fuel and autophagy in cancer cell survival (2010-2013).
- Fondazione Roma– Intervention Program to sustain the Biomedical research “Type 2 Diabetes Mellitus: Role of Inflammation and Innate Immunity in The Pathogenesis of Endothelial Dysfunction and Atherosclerosis” (2009-2012).
- INCT de Processos Redox em Biomedicina – Redoxoma (Apoio FAPESP/CNPq/MCT) (2009-2014).
- MIUR – PRIN 2007, 20077S9A32 (Coordinatore Scientifico Nazionale) “Redox mechanisms underlying cell signaling involved in the genesis of oxidative stress-related diseases” (2008-2010).
- Projeto Bilateral, Programa Executivo Brasil-Itália, Processo CNPq 490021/2008-5. Characterization of oxidative damage caused by copper complexes: molecular bases for their antitumor action”(2008).
- Ministero della Salute, RF-2009-1546096 “Role of recurrent herpetic infections in neuronal damage” (2007-2009).
- FIRB – RBIP063ANC_003 “New Neurotrophic and neuroprotective drugs for therapeutic applications in neurosciences: Alzheimer’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis” (2007-2010).
- FAPESP – No. 05/60596-8 Espécies Complexas com Potencial Aplicação em Bioinorgânica, Catálise, Farmacologia e Química Ambiental: concepção, preparação, caracterização e reatividade (2006-2010).

ATTIVITA’ DI RICERCA
- Glutatione ed enzimi antiossidanti nel controllo del metabolismo delle specie reattive dell’ossigeno e dell’ossido nitrico. Alterazione di tali processi in patologie redox (cancro, degenerazioni, diabete tipo2, aterosclerosi);
- Metabolismo dell’ossido nitrico e regolazione delle ossido nitrico sintasi;
- Segnalazione redox e fosforilativa in modelli sperimentali di tumori, neurodegenerazione ed infezione virale;
- Trasduzione del segnale redox in processi cellulari (proliferazione, differenziamento, autofagia, apoptosi);
- Controllo della funzione e turnover dei mitocondri (biogenesi/mitofagia);
- De-regolazione del metabolismo (lipidi, amino acidi, glucosio) in cellule cancerose;
- Effetti dei nutrienti e nutraceutici (polifenoli e composti organosolfurici) sull’omeostasi redox, epigenetica e metabolismo cellulare ossidativo.

SELECTED PUBBLICATIONS
1. Desideri, E., Filomeni, G. and Ciriolo, M.R.(2012) Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells. Autophagy 8: 1769-1781.
2. Aquilano, K., Baldelli, S., Pagliei, B., Cannata, S., Rotilio,G. and Ciriolo, M.R.(2012)p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance. Antiox. Redox Signal. 18: 386-399.
3. Cardaci, S., Rizza, S., Filomeni, G., Bernardini, R., Bertocchi, F., Mattei, M., Paci, M., Rotilio, G. and Ciriolo, M.R.(2012) Glutamine deprivation enhances antitumor activity of 3-bromopyruvate through the stabilization of monocarboxylate transporter-1. Cancer Res. 72:4526-4536.
4. Cardaci, S., Filomeni, G. and Ciriolo, M.R.(2012)Redox implications of AMPK-mediated signal transduction beyond energetic clues. J. Cell Sci. 125: 2115-2125.
5. Filomeni, G., Graziani, I., De Zio, D., Dini, L., Centonze, D., Rotilio, G. and Ciriolo, M.R. (2012) Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson’s disease. Neurobiology of Aging 33: 767-785.
6. Aquilano, K., Baldelli, S., Cardaci, S., Rotilio, G. and Ciriolo M.R.(2011) Nitric oxide is the primary mediator of cytotoxicity induced by GSH depletion in neuronal cells.J Cell Sci. 124: 1043-1054.
7. Filomeni, G., Desideri, E., Cardaci, S., Piccirillo, S., Graziani, I., Rotilio, G. and Ciriolo, M.R.(2010) Carcinoma cells activate AMP-activated protein kinase-dependent autophagy as survival response to kaempferol-mediated energetic impairment. Autophagy 6: 202-216.
8. Aquilano, K., Vigilanza, P., Filomeni, G., Rotilio, G. and Ciriolo, M.R. (2010) Tau dephosphorylation and microfilaments disruption are upstream events of the anti-proliferative effects of DADS in SH-SY5Y cells. J.Cell.Mol.Med. 14:564-577.
9. Piccirillo,S., Filomeni,G., Brüne,B., Rotilio, G. and Ciriolo, M.R.(2009) Redox mechanisms involved in the selective activation of Nrf2-mediated resistance versus p53-dependent apoptosis in the adenocarcinoma gastric cells AGS. J BiolChem 284: 27721-27733.
10. Vigilanza,P., Aquilano,P., Rotilio,G. and Ciriolo, M.R.(2008) Transient cytoskeletal alterations after SOD1 depletion in neuroblastoma cells. Cell.Mol. Life Sci. 65: 991-1004.
11. Aquilano,K., Vigilanza,P., Rotilio,G. and Ciriolo, M.R.(2006) Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1. FASEB J. 20: 1683-1685.
12. Filomeni,G., Aquilano,K., Rotilio,G. and Ciriolo, M.R. (2005) Glutathione-related systems and modulation of extracellular signal-regulated kinases are involved in resistance of AGS adenocarcinoma gastric cells to diallyl disulfide-induced apoptosis. Cancer Res. 65, 11735-11742.
13. Ciriolo, M.R. (2005) Redox control of apoptosis. Antiox.Redox Signal 7: 430-433.
14. Filomeni,G., Aquilano,k., Rotilio,G and Ciriolo, M.R. (2003) Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide. Cancer Res. 63: 5940-5949.
15. Filomeni,G., Rotilio,G. and Ciriolo,M.R. (2002)Glutathione disulfide induces apoptosis of U937 cells by a redox-mediated p38 MAP kinase pathway. FASEB J. 17: 64-66.
16. Angelini,G., Gardella,S., Ardy,M., Ciriolo, M.R., Filomeni,G., Di Trapani,G., Clarke,F., Sitia,R. and Rubartelli,A. (2002) Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation. Proc.Natl.Acad.Sci. (USA) 99: 1491-1496.
17. Ciriolo, M.R., De Martino,A., Lafavia,E., Rossi,L., Carrì,M.T. and Rotilio,G. (2000) Cu,Zn-superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells. J.Biol.Chem. 275: 5065-5072.
18. Ghibelli,L., Coppola,S., Fanelli,C., Rotilio,G., Civitareale,P., Scovasassi, A.I. and Ciriolo, M.R.(1999) Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis. FASEB J. 13: 2031-2036.
19. Ghibelli,L., Fanelli,C., Rotilio,G., Lafavia,E., Coppola,S., Colussi,C., Civitareale,P. and Ciriolo, M.R. (1998) Rescue of cellsfromapoptosis by inhibition of active GSH extrusion. FASEB J. 12: 479-486.
20. Ciriolo, M.R.,Palamara,A.T., Incerpi,S., Lafavia,E., Buè,M.C., De Vito,P., Garaci,E. and Rotilio,G. (1997) Loss of GSH, oxidative stress and decrease of intracellular pH as sequential steps in viral infection. J.Biol.Chem. 272: 2700-2708.

RESEARCH GROUP AND CONTACTS
Maria Rosa Ciriolo – Full Professor – ciriolo@bio.uniroma2.it
Katia Aquilano – Researcher – katia.aquilano@uniroma2.it
Giuseppe Filomeni – Researcher – filomeni@uniroma2.it
Enrico Desideri – Staff Scientist – desideri.enrico@fastwebnet.it
Sara Baldelli – Staff Scientist            – sara.baldelli@uniroma2.it
Giuseppina Di Giacomo – Staff Scientist – giuseppinadigiacomo@yahoo.it
Daniele Lettieri Barbato – PhDstudent – daniele.lettieri.barbato@uniroma2.it
Costanza Montagna – PhDstudent – costanza.montagna@libero.it
Giuseppe Tatulli – PhDstudent – giuseppe.tatulli@hotmail.it
Salvatore Rizza – PhDstudent           – salvatoreri@gmail.com
Rolando Vegliante – PhDstudent – veglianterolando@tiscali.it
Patrizia Civitareale – Technician – civitareale@uniroma2.it