Maurizio Mattei   

Curriculum Vitae
Maurizio Mattei is Associate Professor of General Pathology and Immunology since 2007 in the scientific field MED/04; researcher at the Department of Biology of the University of Rome Tor Vergata since 2001.
In the same year on behalf of DGCS -MAE plays the role of project leader in the project entitled ” Rehabilitation of the Institute Pasteur in Tangier “. From 2006 to 2008, on behalf of ICE , at The Ministry of Health of Bulgaria-European Affairs and International Cooperation of Sofia, covers the role of expert in the field of Health as part of the Italian law on the Balkans (L.84/2001). Currently lecturer in Immunology in the course of first and second degree level, respectively for Biology and Medical Biotechnology courses; for the first-level course in Biotechnology is the owner of the course in Laboratory Animals. From 2002 to 2012 he held the position of Technical Director at the Center for Interdisciplinary Service-Station for Animal Technology; since 2012 is General Coordinator of the same Center. Since 2009, covers the role of inspector for “Accredia” for the accreditation of medical laboratories. Member of the Board of Doctorate in “Immunology and Applied Biotechnology” where he was a lecturer and tutor guidance. He is the author of 50 publications in peer reviewed journals and a patent.

Research topics
The research activity is mainly focused in the study and in the use of animal models in the field of experimental oncology and infectious diseases. The development of new vaccines currently occupies a predominant part of the research, in terms of: natural adjuvants (BCG), use of peptides and use of new delivery systems on micro / nanoscale, in the field of biomedical and veterinary research ( e.g.hepatitis B, leishmaniasis). Moreover, in collaboration with other research groups, the use of peptides is adopted in the study of delayed type hypersensitivity reactions (DTH) and in the diagnosis of infectious diseases (eg tuberculosis). The use of animal models is finally used in research and in the safety of new materials for applications in the field of human prostheses.

Research funding (last 5 years)
-4 Co-Research projects Filas, Lazio Region;
-Ricerca finalizzata on leishmaniasis and toxoplasmosis
-VII FP- De.v.a.n.i. project: a subcontractor for the development of an animal model in neonatal infections by S. agalctiae (GBS).

Selected Publications
1. Mattei M., Gorini A., Lavaggi M.V., Sumerska T., Politi E.& Colizzi V. Immunomodulating activity of a synthetic peptide derived from snake venom. J. Chemotherapy III, 160-164, 1991.
2. Poccia F., Piselli P., Di Cesare S., Colizzi V., Mattei M.., Bolognesi A., Stirpe F. Recognition and killing of tumour cells expressing heat shock protein 65KD with immunotoxin containing saporin. Br.J. Cancer 65, 427-432, 1992.
3. Lombardi V., Placido R., Scarlatti G., Romiti L., Mattei M., Mariani F., Poccia F., Rossi P. & V. Colizzi. Epitope specificity, antibody dependent cellular cytotoxicity and neutralizing activity of anti HIV-1 antibodies present in autoimmune MRL/lpr mice. J. Infect. Dis. 167, 1267, 1993.
4. Bellavia A., Mattei M., Dieli F., Salerno A., Caroleo M.C., Nisticò G., Asherson G.L. & Colizzi V. Augmented passive transfer of contact sensitivity in SCID mice and its dependence of V8+cells in the picryl system. Int. Arch. All. Appl. Immunol. 101,402-407, 1993.
5. Zembala M.; Siedlar M., Ruggiero I.,Wieckiewicz j., Mystar B., Mattei M., and Colizzi V. The MHC class II and CD-44 molecules are involved in the induction of tumor necrosis factor (TNF) gene expression by human monocytes stimulated with tumor cells. Int. J. Cancer. 56,269-274, 1994.
6. Mattei M., Bach S., Di Cesare S., Fraziano M., Placido R., Poccia F., Sammarco I., Moras A.M., Bardone M.R. and Colizzi V. CD4-8- T cells increase in MRL/lpr mice treated with thymus factor. Int. J. Immunoph. 8: 651-658, 1994.
7. Piacentini M., Piredda L., Starce D., Petruzzelli-Annichiarico M., Mattei M., Oliverio S. Farrace M.G. and Melino G. Differenzial growth od N- and S type human neuroblastoma cells xenografted into SCID mice. Correlation with apoptosis. Journal of Pathology. 180: 415-422, 1996.
8. Fattorini L., Xiao Y., Mattei M., Li Y., Iona E., Ricci M.L., Thoresen O.F., Creti R., and Orefici G. Activities of isoniazide alone and in combination with other drugs against M. avium infection in beige mice. Antim. Agent and Chemot. 42, 712-714, 1998.
9. M. Mattei, E. Carnieri, V. Politi, S. D’Alessio, A. Sella, M. Cassol, A. Robeva, V. Colizzi and T. Sumerska. Inhibition of contact hypersensitivity reaction (CHR) to pycril chloride- effect of small molecular weight peptidomimetic compounds possessing inhibitory activity against metalloproteinases. Intern. Immunoph. 2, 699-710, 2002.
10. L. Fattorini, D. Tan, E. Iona, M. Mattei, F. Giannoni, L. Brunori, S. Recchia and G. Orefici. Activities of Moxifloxacin Alone and in combination with Other Anticrobial Agents against Multidrug-resistant M. tuberculosis Infection in BALB/c mice. Antimicrobial Agents and Chemotherapy. 360-362 Jan. 2003.
11. Rita Casetti, Gemma Perretta, Alessandra Taglioni, Maurizio Mattei, Vittorio Colizzi, Miroslav Malkovsky, Francesco Dieli, Gianpiero D’Offizi, and Fabrizio Poccia .Drug-induced expansion and differentiation of Vg9Vd2 T cells in vivo: the role of exogenous IL-2. J. Immunol. 175: 1593-1598, , 2005.
12. P. Turella, C. Cerella, G. Filomeni, A. Bullo, F. De Maria, L. Ghibelli, M.R. Circolo, M. Cianfruglia, M. Mattei, G. Federici, G. Ricci, and A.M. Caccuri. Pro apoptotic activity of new glutatione S-transferase inhibitors. Cancer Research. 65: 9, 2005..
13. P. Rossi, A. De Majo, A. Mauti, V. Quattrini, M. Mattei, V. Rognoni, L. Cenci, A. Manzelli, N. Di Lorenzo & A. L. Gaspari. Bloodless hepatic resection with automatic bipolar radiofrequency generator and multielectrod device. Minimally Invasive Therapy. 16:1; 66-72, 2007.
14. Pedersen JZ, De Maria F., Turella P., Federici G.,. Mattei M, Fabrini R., Dawood KF., Massimi M., Caccuri AM., Ricci G. Glutathione transferases sequester toxin dinitrosyl-iron complexes in cells. A protection mechanism against excess nitric oxide. J. Biol. Chem. Mar 2; 282(9): 6364-71, 2007.
15. Daniela Alesiani, Rosella Cicconi, Maurizio Mattei, Carla Montesano, Roberto Bei, and Antonella Canini,. Cell cycle arrest and differentiation induction by 5,7-dimethoxycoumarin on melanoma cell lines. Int. J. Oncology 32: 425-434, 2008
16. Gonfloni S, Di Tella L, Caldarola S, Cannata SM, Klinger FG, Di Bartolomeo C, Mattei M, Candi E, De Felici M, Melino G, Cesareni G.. Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nat Med. 2009 Oct;15(10):1179-85. Epub 2009 Sep 27.
17. Speranza V, Colone A, Cicconi R, Palmieri G, Giovannini D, Grassi M, Mattei M, Sali M, Delogu G, Andreola F, Colizzi V, Mariani F. Recombinant BCG-Rv1767 amount determines, in vivo, antigen-specific T cells location, frequency, and protective outcome. Microb Pathog. 2010 May;48(5):150-9. Epub 2010 Feb. 26
18. Pichichero E, Cicconi R, Mattei M, Muzi MG, Canini A.Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. Int J Oncol. 2010 Oct;37(4):973-
19. Turriziani M, Modesti M, Forni G, Schlom J, Modesti A, Bei R. Local delivery of recombinant vaccinia virus encoding for neu counteracts growth of mammary tumors more efficiently than systemic delivery in neu transgenic mice.Cancer Immunol
20. Pica F, Balestrieri E, Serafino A, Sorrentino R, Gaziano R, Moroni G, Moroni N, Palmieri G, Mattei M, Garaci E, Sinibaldi-Vallebona P. Antitumor effects of the benzophenanthridine alkaloid sanguinarine in a rat syngeneic model of colorectal cancer .Anticancer Drugs. 2012 Jan;23(1):32-42
21. Simone Cardaci, Salvatore Rizza, Giuseppe Filomeni, Roberta Bernardini, Fabio Bertocchi, Maurizio Mattei, Maurizio Paci, Giuseppe Rotilio, and Maria Ciriolo (2012). Glutamine deprivation enahances antitumo activity of 3-bromopyruvate through the stabilization of monocarboxylate transporter-1 1. Cancer Res. 2012 Sep 1;72(17):4526-36
22. Sacchetti, Cristiano; Motamedchaboki, Khatereh; Magrini, Andrea; Palmieri, Graziana; Mattei, Maurizio; Bernardini, Sergio; Rosato, Nicola; Bottini, Nunzio; Bottini, Massimo Surface Polyethylene Glycol Conformation Influences the Protein Corona of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Potential Implications on Biological Performance. ACS Nano, 2013 Mar 26;7(3):1974-89
23. Sacchetti C, Rapini N, Magrini A, Cirelli E, Bellucci S, Mattei M, Rosato N, Bottini N, Bottini M. In vivo targeting of intratumor regulatory T cells using PEG-modified single-walled carbon nanotubes. Bioconjug Chem. 2013 Jun 19;24(6):852-8.
24. Sarra M, Cupi ML, Bernardini R, Ronchetti G, Monteleone I, Ranalli M, Franzè E, Rizzo A, Colantoni A, Caprioli F, Maggioni M, Gambacurta A, Mattei M, Macdonald TT, Pallone F, Monteleone G. IL-25 prevents and cures fulminant hepatitis in mice through a myeloid-derived suppressor cell-dependent mechanism. Hepatology. 2013 Oct;58(4):1436-50
25. Rossi P, Bove P, Montuori M, De Majo A, Ricciardi E, Mattei M, Bernardini R, Calzetta L, Mauti P, Intini L, Quattrini V, Chiaramonte C, Vespasiani G. Partial nephrectomy using radiofrequency incremental bipolar generator with multi electrode probe: experimental study in bench pig kidneys. BMC Urol. 2014 Jan 10;14:7.

Research group
Maurizio Mattei, Tel. 06-7259-6369 E-Mail mattei@uniroma2.it Web www.sta.uniroma2.it/; http://immuno.bio.uniroma2.it/lab/