Andrea Novelletto      Bandiera-Tricolore-Italiana


1980 Degree in Biological Sciences,University of Rome.
1983 Ph.D. (cum laude), Medical Genetics,University of Rome

1981 Research fellow, Public Health Institute (biostatistics)
1982 Military service
1983-84 Research fellow, Inst. Cell Biology of the National Research Council (molecular genetics)
1986-93 Visiting researcher, Genetics Unit, Mansoura University (Egypt). Field research on the hemoglobinopathies.
1989-90 Visiting researcher, Al Wasl Pediatric Hosp., Dubai, U.A.E.. Field research on the hemoglobinopathies.
1987-96 Visiting researcher, Massachusetts General Hosp., Boston, U.S.A.. Molecular genetics of neurodegenerative disorders.

1984-98 Assistant Professor, Dept. of Biology, 2nd University of Rome.
1998-01 Associate Professor, Dept. of Cell Biology, University of Calabria, Italy.
2001-05 Professor of Genetics, Dept. of Cell Biology, University of Calabria, Italy.
2005 Professor of Genetics, Dept. of Biology, University “Tor Vergata”, Rome, Italy.

GRANTS AWARDED (2000-2009) :
2000-2001 Italian National Coordinator, CNR programme -Agenzia 2000
1999-2001 NATO country Coordinator, Collaborative Linkage Grant NATO LST.CLG975057 “A population genetic survey in Southern Caucasus”
2002-2004 Local coordinator, MURST-PRIN Programme 2002
2003-2005 Local coordinator, MURST-PRIN Programme 2003
2002-2004 Participant, Italian-Russian Inter-governmental technology agreement “A DNA bank representative of human genetic biodiversity in the Russian population”
2004-2005 NATO country Coordinator, Linkage Grant NATO PDD(CP)(LST.CLG 980469) “Changes in the nutritional pattern in populations of Eastern Siberia”
2005-2007 Local coordinator, MURST-PRIN Programme 2005
2007-2009 Local coordinator, MURST-PRIN Programme 2007
2008 Dissemination grant on “Disseminating conservation biology: a scientific account for the public on the monitoring, genetics and conservation of marine turtles”. Ital. Ministry of Public Education
2009 Dissemination grant on “Reduction of biodiversity: consequences for food resources, the environment and the human species”. Ital. Ministry of Public Education

Annals of Human Biology

American Journal of Human Genetics
American Journal of Physical Anthropology
Annals of Human Biology
Annals of Human Genetics
DNA and Cell Biology
European Journal of Human Genetics
FEBS letters
Forensic Sci. Intl.
Journal of Neurology
Molecular phylogenetics and evolution
Proc. Natl. Acad. Sci. USA
Theoretical Population Biology

Associazione Genetica Italiana
Societa’ Italiana di Genetica Umana
European Association of Human Biologist
Society for Molecular Biology and Evolution

Ecology and Evolution, University “Tor Vergata”.

D.Ph, University of Oxford, U.K., 2002
Dottorato in Neuroscienze, U.C.S.C., Roma, 2004.

Luria, Gould, Singer: A view of life. Zanichelli ed., Bologna
Hartl: Human genetics. Zanichelli ed., Bologna
Weatherall: The new genetics and clinical practice. Zanichelli ed., Bologna
Eisenck, Kamin: Intelligence: a battle for the mind. Laterza ed., Bari
Frankham, Ballou, Briscoe: A primer of conservation genetics. Cambridge University press

1998-2005: Promoter and curator, UNICAL OPENLAB

2007-2010: Director, Master in Science Dissemination,

University “Tor Vergata”, Rome, Italy

Dpto. de Zoologia y Antropologia Fisica Facultad de Biologia Universidad Complutense 28040 MADRID (Espana)
Laboratory for Archaeogenetics Institute of Archaeology Letenska 4, 118 01, Prague 1 Czech Rep.


Trombetta B, D’Atanasio E, Massaia A, Myres NM, Scozzari R, Cruciani F, Novelletto A. 2015.
Regional differences in the accumulation of SNPs on the male-specific portion of the human Y chromosome replicate autosomal patterns:
implications for genetic dating. PLoS ONE 10: e0134646

Trombetta B, D’Atanasio E, Massaia A, Ippoliti M, Coppa A, Candilio F, Coia V, Russo G, Dugoujon JM, Moral P, Akar N, Sellitto D, Valesini G, Novelletto A, Scozzari R, Cruciani F. 2015.
Phylogeographic refinement and large scale genotyping of human Y chromosome haplogroup E provide new insights into the dispersal of early pastoralists in the African continent. Genome Biol Evol 7:1940-1950

Polimanti R, Piacentini S, Iorio A, De Angelis F, Kozlov A, Novelletto A, Fuciarelli M. 2015.
Haplotype differences for copy number variants in the 22q11.23 region among human populations: a pigmentation-based model for selective pressure. Eur J Hum Genet 23:116-123

Doro MG, Piras D, Leoni GG, Casu G, Vaccargiu S, Parracciani D, Naitana S, Pirastu M, Novelletto A. 2014. Phylogeny and patterns of diversity of goat mtDNA haplogroup A revealed by resequencing complete mitogenomes. PLoS ONE 9:e95969

Hernández CL, Reales G, Dugoujon J-M, Novelletto A, Rodríguez JN, Cuesta P, Calderon R. 2014.
Human maternal heritage in Andalusia (Spain): its composition reveals high internal complexity and distinctive influences of mtDNA haplogroups U6 and L in the Western and Eastern side of region. BMC Genetics 15:11-16

Scozzari R, Massaia A, Trombetta B, Bellusci G, Myres NM, Novelletto A, Cruciani F. 2014. An unbiased resource of novel SNP markers provides a new chronology for the human Y chromosome and reveals a deep phylogenetic structure in Africa. Genome Res 24:535-544

Reales G, Hernández CL, Dugoujon JM, Novelletto A, Fortes-Lima C, Rodríguez JN, Calderón R. 2013.
New insights into the distribution of APOE polymorphism in the Iberian Peninsula. The case of Andalusia (Spain). Ann Hum Biol 41:443-452

Veneziano L, Mantuano E, Catalli C, Gellera C, Durr A, Romano S, Spadaro M, Frontali M, Novelletto A. 2013. A shared haplotype for dentatorubropallidoluysian atrophy (DRPLA) in Italian families testifies of the recent introduction of the mutation. J Hum Genet 59:153-157

Garofalo L, Casale P, Carlini R, Eleni C, Freggi D, Gelli D, Knittweis L, Mifsud C, Mingozzi T, Novarini N, Scaravelli D, Scillitani G, Oliverio M, Novelletto A. 2013. Genetic characterization of central Mediterranean stocks of the loggerhead turtle (Caretta caretta) using mitochondrial and nuclear markers, and conservation implications. Aquatic Cons: Mar Freshw Ecosyst DOI: 10.1002/aqc.2338

Bucková J, Cerný V, Novelletto A. 2013. Multiple and differentiated contributions to the male gene pool of pastoral and farmer populations of the African Sahel. Am J Phys Anthropol 151:10-21

Ramos EM, Latourelle JC, Lee J-H, Gillis T, Mysore JS, Squitieri F, Di Donato S, Hayden MR, Morrison P, Nance M, Ross CA, Margolis RL, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire M-H, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Gusella JF, Lee J-M, Alonso I, Sequeiros J, Myers RH, MacDonald ME. 2012. Population stratification may bias analysis of PGC-1a as a modifier of age at Huntington disease motor onset. Hum Genet 131:1833-1840

Lee J-H, Lee J-M, Ramos E, Gillis T, Mysore J, Kishikawa S, Hadzi T, Hendricks A, Hayden M, Morrison P, Nance M, Ross C, Margolis R, Squitieri F, Gellera C, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent R, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire M, Hersch S, Rosas H, Lucente D, Harrison M, Zanko A, Abramson R, Marder K, Sequeiros J, Landwehrmeyer B, Shoulson I, Myers R, MacDonald M, Gusella J. 2012. TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington’s disease. Biochem Biophys Res Commun 424:404-408

Garofalo L, Zaccaroni A, Scaravelli D, Insacco G, Zangrilli MP, Novelletto A, Lorenzini R. 2012. Morphology vs Genetics: the hybrid origin of a sea turtle disproved by DNA. Mediterranean Marine Science 13:239-242

Lee J-M, Gillis T, Srinidhi Mysore J, Ramos EM, Myers RH, Hayden MR, Morrison P, Nance M, Ross CA, Margolis RL, Squitieri F, Griguoli A, DiDonato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire M-H, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson R, Marder K, Sequeiros J, MacDonald ME, Gusella JF. 2012. Common SNP-based haplotype analysis of the 4p16.3 Huntington’s Disease gene region. Am J Hum Genet 90:434-444.

Piras D, Doro MG, Casu G, Melis MP, Vaccargiu S, Piras I, Parracciani D, Stradoni R, Frongia B, Lai G, Sale S, Cattari W, Piras R, Querci O, Demuro PG, Cui S, Atzori F, Mancosu M, Marchiori F, Cammelli R, Spiga A, Loddo PP, Pili G, Boi R, Argiolas G, Mereu P, Leoni GG, Naitana S, Pirastu M, Novelletto A. 2012. Haplotype affinities resolve a major component of goat (Capra hircus) mtDNA D-loop diversity and reveal specific features of the Sardinian stock. PLoSONE 7:e30785

Lee J-M, Ramos EM, Lee J-H, Gillis T, Mysore JS, Hayden MR, Warby SC, Morrison P, Nance M, Ross CA, Margolis RL, Squitieri F, Orobello S, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJA, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson R, Marder K, Sequeiros J, Paulsen JS, Landwehrmeyer GB, Myers RH, MacDonald ME, Gusella JF. 2012. CAG repeat expansion in Huntington’s disease determines age at onset in a fully dominant fashion. Neurology 78: 690-695

Novelletto A, Gulli R, Ciotti P, Vitale C, Malaspina P, Blasi P, Pippucci T, Seri M, Cozzolino A, Bilo L, Abbruzzese G, Martinelli P, Bellone E, Barone P, Mandich P. 2011. Linkage exclusion in Italian families with hereditary Essential Tremor. Eur J Neurol 18:e118-120

Ambrosio B, Novelletto A, Hernandez C, Dugoujon JM, Fortes-Lima C, Rodriguez JN, Calderon R. 2011. Y-STR genetic diversity in autochthonous Andalusians from Huelva and Granada provinces (Spain). Forensic Sci Int Genet 6: e66-71

Garofalo L, Borg JJ, Carlini R, Mizzan L, Novarini N, Scillitani G, Novelletto A. 2011. Genetic characterization of over hundred years old Caretta caretta specimens from Italian and Maltese museums. Acta Herpetol 6:27-34

King RJ, DiCristofaro J, Kouvatsi A, Triantaphyllidis C, Scheidel W, Myres NM, Lin AA, Eissautier A, Mitchell M, Binder D, Semino O, Novelletto A, Underhill PA, Chiaroni J. 2011. The coming of the Greeks to Provence and Corsica: Y-chromosome models of archaic Greek colonization of the western Mediterranean. BMC Evol Biol 11: 69

Cerný V, Pereira L, Musilová E, Kujanová M, Vašíková A, Blasi P, Garofalo L, Soares P, Diallo I, Brdicka R, Novelletto A. 2011. Genetic structure of pastoral and farmer populations in the African Sahel. Mol Biol Evol 28:2491-2500

Ambrosio B, Hernández C, Novelletto A, Dugoujon JM, Rodríguez JN, Cuesta P, Fortes-Lima C, Calderón R. 2010. Searching the Peopling of the Iberian Peninsula from the perspective of two Andalusian subpopulations: a study based on Y-chromosome. Haplogroups J and E. Coll Antropol 34: 1215–1228

Bellusci G, Blasi P, Vershubsky G, Suvorov A, Novelletto A, Kozlov A. 2010. The landscape of Y chromosome polymorphisms in Russia. Ann Hum Biol 37: 367-384

Ambrosio B, Dugoujon JM, Hernández C, de la Fuente D, González-Martín A, Fortes-Lima C, Novelletto A, Rodríguez CN, Calderón R. 2010. The Andalusian population from Huelva reveals a high diversification of Y-DNA paternal lineages from haplogroup E: Identifying human male movements within the Mediterranean space. Ann Hum Biol 37: 86-107

Garofalo L, Carlini R, Novelletto A. 2009. Diffusione della Biologia della Conservazione: un rendiconto scientifico sul monitoraggio, la genetica e la conservazione delle tartarughe marine. Museologia Scientifica 6:146-151

Garofalo L, Mingozzi T, Micò A, Novelletto A. 2009. Loggerhead turtle (Caretta caretta) matrilines in the Mediterranean: further evidence of genetic diversity and connectivity. Mar Biol 156: 2085-2095

Luca F, Bubba G, Basile M, Brdicka R, Michalodimitrakis E, Rickards O, Vershubsky G, Quintana-Murci L, Kozlov AI, Novelletto A. 2008. Multiple advantageous amino acid variants in the NAT2 gene in human populations. PLoS ONE 3(9): e3136

Pompei F, Cruciani F, Scozzari R, Novelletto A. 2008. Phylogeography of Y chromosomal haplogroups as reporters of Neolithic and post-Neolithic population processes in the Mediterranean area. Documenta Praehistorica XXXV: 55-64

Cruciani F, Trombetta B, Novelletto A, Scozzari R. 2008. Recurrent mutation in SNPs within Y chromosome E3b (E-M215) haplogroup: A rebuttal. Am J Hum Biol. 20:616-616

De Rango F, Leone O, Dato S, Novelletto A, Bruni AC, Berardelli M, Mari V, Feraco E, Passarino G, De Benedictis G. 2008. Cognitive functioning and survival in the elderly: the SSADH C538T polymorphism. Ann Hum Genet 72: 630-635

De Rango F, Dato S, Bellizzi D, Rose G, Marzi E, Cavallone L, Franceschi C, Skytthe A, Jeune B, Cournil A, Robine JM, Gampe J, Vaupel JW, Mari V, Feraco E, Passarino G, Novelletto A, De Benedictis G. 2008. A novel sampling design to explore gene-longevity associations: the ECHA study. Eur J Hum Genet 16:236-242